PBIT

Item no.	TMO-T16435-10mM
Manufacturer	TargetMol
Amount	1mL*10mM(inDMSO)
Category	SALE Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2514-30-9
Available
purity	99.95%
SMILES	O=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3
formula	C14H11NOS
MolWt	241.31
Pathway	Chromatin/Epigenetic
Target	Histone Methyltransferase
Receptor	JARID1A; JARID1B; JARID1C
Bioactivity	PBIT inhibits JARID1B histone demethylase (IC50 of about 3 uM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 uM and 4.9 uM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes .
Reference	Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29; 288(13):9408-17.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1mL*10mM(inDMSO)

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