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Apricitabine

Apricitabine

Item no.	TMO-T14313-50mg
Manufacturer	TargetMol
CASRN	160707-69-7
Amount	50 mg
Quantity options	100 mg 10 mg 1 mL 1 mg 25 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	O=C1N([C@@H]2S[C@H](CO)OC2)C=CC(N)=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SPD754, AVX754
Shipping condition	Cool pack
Available
Manufacturer - Targets	HIV Protease\|\|\|DNA/RNA Synthesis
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	229, 26
Target names or alias	AVX754 , SPD754
Description	Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.
Pathways	Proteases/Proteasome\|\|\|Cell Cycle/Checkpoint\|\|\|DNA Damage/DNA Repair\|\|\|Microbiology/Virology

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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