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Mivebresib (ABBV-075)

Mivebresib (ABBV-075)

Manufacturer	Selleckchem
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	25 mg
Item no.	S8400-25
CASRN	1445993-26-9
eClass 6.1	30220300
eClass 9.0	32160605
Available
Alias	1445993-26-9'
Information	Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.

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Amount: 25 mg

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Delivery expected until 7/26/2024

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