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Roxadustat (FG-4592)

Roxadustat (FG-4592)

Item no.	S1007-1000
Manufacturer	Selleckchem
CASRN	808118-40-3
Amount	1 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ASP1517, HIF alpha prolyl hydroxylase;HIF
Similar products	FG-4592
Available
Chemical Name	2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetic acid
Clinical Trials	A phase II clinical trial of FG-4592 has been competed in the treatment of chronic kidney disease.
Description	FG-4592 is an HIF alpha prolyl hydroxylase inhibitor.
In vitro	FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. [1]
Molecular Weight (MW)	352, 34
Picture ChemicalStructure Description	FG-4592 Chemical Structure
Solubility (25C)	DMSO 71 mg/mL, Water <1 mg/mL, Ethanol <1 mg/mL
Storage	2 years -20CPowder, 2 weeks4Cin DMSO, 2 months-80Cin DMSO

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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