CPTH2

Item no.	HY-W013274-50mg
Manufacturer	MedChem Express
CASRN	357649-93-5
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.82
Formula	C14H14ClN3S
Citations	[1]Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44.<br/>[2]Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J Med Chem. 2009 Jan 22;52(2):530-6.
Smiles	ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	357649-93-5
Available
Product Description	CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	291.80
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)\|Ethanol : 1 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic)
Target	Apoptosis; Histone Acetyltransferase
Manufacturers Target	Apoptosis; Histone Acetyltransferase
Isoform	GCN5/PCAF
Manufacturers Pathway	Apoptosis; Epigenetics
Manufacturers Product type	Reference compound

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