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Uridine-5'-diphosphate disodium salt

Uridine-5'-diphosphate disodium salt

Item no.	HY-W010832-10mM
Manufacturer	MedChem Express
CASRN	27821-45-0
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.0
Formula	C9H12N2Na2O12P2
Citations	[1]Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89.<br/>[2]Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9.<br/>[3]Edyta Gendaszewska-Darmach, et al. Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation. Oncotarget. 2016 Oct 25;7(43):69358-69370.<br/>[4]Zainab S B Abbas, et al. UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascul Pharmacol. 2018 Apr;103-105:36-46.
Smiles	O[C@H]1[C@H](N(C=CC2=O)C(N2)=O)O[C@H](COP(OP(O)(O[Na])=O)(O[Na])=O)[C@H]1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	27821-45-0
Available
Product Description	Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	448.12
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : < 1 mg/mL\|H2O : 100 mg/mL (ultrasonic)
Target	DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor
Manufacturers Target	DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor
Isoform	P2Y6 Receptor
Manufacturers Pathway	Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-W010832-10mM-safety-datasheet.pdf