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Inclacumab

Inclacumab

Item no.	HY-P99263-5mg
Manufacturer	MedChem Express
CASRN	1256258-86-2
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.80
Dry ice	Yes
Citations	[1]Xin Geng, et al. Inclacumab, a Fully Human Anti-P-Selectin Antibody, Directly Binds to PSGL-1 Binding Region and Demonstrates Robust and Durable Inhibition of Cell Adhesion. Blood (2020) 136 (Supplement 1): 10–11.<br>[2]Kling D, et al. Pharmacological control of platelet-leukocyte interactions by the human anti-P-selectin antibody inclacumab--preclinical and clinical studies. Thromb Res. 2013 May;131(5):401-10.<br>[3]Tarasev M, et al. S107: P-SELECTIN INHIBITOR INCLACUMAB REDUCES CELL ADHESION IN AN IN-VITRO ASSAYS SHOWING POTENTIAL FOR PREVENTION OF VASO-OCCLUSION EVENTS IN SICKLE CELL DISEASE. Hemasphere. 2022 Jan 31;6(Suppl ):3-4.
Smiles	[Inclacumab]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Anti-Human selectin P Recombinant Antibody
Available
Product Description	Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion[1][2][3].
StorageTemperature	Store at -80°C for 2 years
Shipping	Dry Ice
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	N/A
Clinical_Information	Phase 3
Manufacturers Research_Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturers Target	P-selectin
Manufacturers Product type	Inhibitory Antibodies

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