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CD70, Mouse (HEK293, Fc)

CD70, Mouse (HEK293, Fc)

Item no.	HY-P72928-200ug
Manufacturer	MedChem Express
Amount	200ug
Category	Inhibitors & Compound Libraries Small Molecules
Type	Peptides
Specific against	other
Purity	96.80
Citations	[1]Bowman MR, et al. The cloning of CD70 and its identification as the ligand for CD27. J Immunol. 1994 Feb 15;152(4):1756-61.<br>[2]Jacobs J, et al. CD70: An emerging target in cancer immunotherapy. Pharmacol Ther. 2015 Nov;155:1-10.<br>[3]Izawa K, et al. Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection. J Exp Med. 2017 Jan;214(1):73-89.<br>[4]Brown GR, et al. CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes. J Immunol. 1995 Apr 15;154(8):3686-95.<br>[5]Kobata T, et al. CD27-CD70 interactions regulate B-cell activation by T cells. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11249-53.<br>[6]Jin L, et al. CD70, a novel target of CAR T-cell therapy for gliomas. Neuro Oncol. 2018 Jan 10;20(1):55-65.<br>[7]Boursalian TE, et al. Targeting CD70 for human therapeutic use. Adv Exp Med Biol. 2009;647:108-19.<br>[8]Arens R, et al. Signaling through CD70 regulates B cell activation and IgG production. J Immunol. 2004 Sep 15;173(6):3901-8.
Smiles	QQQRLLEHPE PHTAELQLNL TVPRKDPTLR WGAGPALGRS FTHGPELEEG HLRIHQDGLY RLHIQVTLAN CSSPGSTLQH RATLAVGICS PAAHGISLLR GRFGQDCTVA LQRLTYLVHG DVLCTNLTLP LLPSRNADET FFGVQWICP
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD70 Protein, Mouse (HEK293, Fc),Mouse,HEK293
Available
Product Description	CD70 is the ligand of CD27 in activated T and B lymphocytes, is an important cytokine in CD70-CD27 pathway involving with the generation and maintenance of T cell immunity[1]. CD70 is a surface antigen, also shows antiviral activity and regulates viability of tumor cells and regulatory T cells[2][3]. As for CD70 protein in mouse contains TNF_2 domain (60-190 a.a) and transmembrane helix, belonging to the tumor necrosis factor (TNF) family. CD70 Protein, Mouse (HEK293, Fc) is 149 amino acids in length (Q47-P195) and is expressed in the HEK293 cells with N terminal mFc-tag.
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
MolecularWeight	Approximately 43.1 kDa
Manufacturers Product type	Recombinant Proteins

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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