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IL-36 beta/IL-1F8, Mouse (153a.a)

IL-36 beta/IL-1F8, Mouse (153a.a)

Item no.	HY-P72546-10ug
Manufacturer	MedChem Express
Amount	10 ug
Quantity options	10 ug 50 ug
Category	Inhibitors & Compound Libraries Small Molecules
Type	Peptides
Specific against	other
Purity	95.63
Citations	[1]Bassoy EY, et al. Regulation and function of interleukin-36 cytokines. Immunol Rev. 2018 Jan;281(1):169-178.<br/>[2]Zhou L,et al. Interleukin-36: Structure, Signaling and Function. Adv Exp Med Biol. 2021;21:191-210.<br/>[3]Gresnigt MS, et al. Biology of IL-36 cytokines and their role in disease. Semin Immunol. 2013 Dec 15;25(6):458-65.<br/>[4]Zhu J, et al. Interleukin-36β exacerbates DSS-induce acute colitis via inhibiting Foxp3+ regulatory T cell response and increasing Th2 cell response. Int Immunopharmacol. 2022 Jul;108:108762.<br/>[5]Zhao X, et al. IL-36β Promotes CD8+ T Cell Activation and Antitumor Immune Responses by Activating mTORC1. Front Immunol. 2019 Aug 7;10:1803.
Smiles	SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC CVEMEGKPTL QLKEVDIMNL YKERKAQKAF LFYHGIEGST SVFQSVLYPG WFIATSSIER QTIILTHQRG KLVNTNFYIE SEK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-36 beta/IL-1F8 Protein, Mouse (153a.a),Mouse,E. coli
Available
Product Description	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases[1][2]. IL-36 beta/IL-1F8 Protein, Mouse (153a.a) is a recombinant mouse IL-36 beta (S31-K183) without any tag, which is produced in E. coli.
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
MolecularWeight	Approximately 16 kDa
Manufacturers Product type	Recombinant Proteins

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Amount: 10 ug

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