Item no. |
HY-P2141-1mg |
Manufacturer |
MedChem Express
|
CASRN |
1234510-46-3 |
Amount |
1 mg |
Quantity options |
100 mg
10 mg
1 ea
1 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.46 |
Formula |
C43H67N13O10 |
Citations |
Eur J Pharmacol. 2023 May 18;175780.<br/>J Am Heart Assoc. 2022 Feb 15;11(4):e022070.<br/>University of Medicine Berlin. 2023 Mar.<br/>[1]Boerrigter G, et al. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure.Circ Heart Fail. 2012 Sep 1;5(5):627-34. Epub 2012 Aug 13.<br/>[2]Liu CH, et al. Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.Nat Commun. 2017 Feb 9;8:14335. |
Smiles |
C[C@H](C(O)=O)NC([C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)=O)=O)=O)CCC1)=O |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Available |
|
Product Description |
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ß-arrestins while blocking G-protein signaling[1]. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment[2]. |
StorageTemperature |
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen) |
Shipping |
Blue Ice |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
926.07 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Cardiovascular Disease |
Solubility |
H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C) |
Target |
Angiotensin Receptor; Arrestin |
Manufacturers Target |
Angiotensin Receptor; Arrestin |
Isoform |
AT1 Receptor |
Manufacturers Pathway |
GPCR/G Protein |
Manufacturers Product type |
Peptides |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.