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Humanin

Humanin

Item no.	HY-P1928-25mg
Manufacturer	MedChem Express
CASRN	330936-69-1
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	95.0
Formula	C119H204N34O32S2
Citations	[1]Guo B, et al. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature. 2003 May 22;423(6938):456-61. <br>[2]Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22;4(7):e6334.
Smiles	O=C([C@H]1N(CCC1)C([C@H](C)NC([C@@H](N)CCSC)=O)=O)N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](C)C(O)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	2687.23
Clinical_Information	No Development Reported
Manufacturers Research_Area	Endocrinology; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target	Bcl-2 Family
Isoform	Bax
Pathway	Apoptosis
Manufacturers Product type	Peptides

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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