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TNF-α (31-45), human (TFA)

TNF-α (31-45), human (TFA)

Item no.	HY-P1860A-50mg
Manufacturer	MedChem Express
Amount	50 mg
Quantity options	100 mg 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Peptides & Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Peptides
Type	Peptides
Specific against	other
Citations	Mol Med Rep. 2019 Oct;20(4):3565-3572.<br/>Biomedicines. 2023 Dec 15, 11(12), 3314.<br/>Cytotechnology. 11 September 2021.<br/>Eur J Pharmacol. 2023 Nov 20:961:176193.<br/>Front Oncol. 2022 Jun 30;12:804439.<br/>[1]Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000 Aug 1;50(3):184-95.<br/>[2]Xi Rui, et al. RPS3 Promotes the Metastasis and Cisplatin Resistance of Adenoid Cystic Carcinoma. Front Oncol. 2022 Jun 30:12:804439.<br/>[3]Jang DI, et al. The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics. Int J Mol Sci. 2021 Mar 8;22(5):2719.
Smiles	OC(C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC(CNC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Product Description	TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	1667.87 (free acid)
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	10 mM in H2O
Target	Apoptosis; NF-κB; TNF Receptor
Manufacturers Target	Apoptosis; NF-κB; TNF Receptor
Isoform	NF-κB
Manufacturers Pathway	Apoptosis; NF-κB
Manufacturers Product type	Peptides

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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