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Gap19 (TFA)

Gap19 (TFA)

Item no.	HY-P1136A-1mg
Manufacturer	MedChem Express
Amount	1 mg
Quantity options	10 mg 1 mg 5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	99.93
Formula	C57H97F3N14O15
Citations	Cell Stress Chaperones. 2024 Apr 21:S1355-8145(24)00067-1.<br/>Research Square Print. 2022 Aug.<br/>Brain Res. 2023 Oct 5:1821:148619.<br/>Oral Dis. 2023 Oct 9.<br/>[1]Boengler K, et al. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013 Jun 6;4:73.<br/>[2]Wang N, et al. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2013 Jan;108(1):309.
Smiles	NCCCC[C@H](N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Product Description	Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial[1][2].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	1275.46
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Target	Gap Junction Protein
Manufacturers Target	Gap Junction Protein
Manufacturers Pathway	Cytoskeleton
Manufacturers Product type	Peptides

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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