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CALP1 (TFA)

CALP1 (TFA)

Item no.	HY-P1077A-1ea
Manufacturer	MedChem Express
Amount	1ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.30
Citations	[1]R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7.<br>[2]R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3.<br>[3]M K Manion, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306.<br>[4]M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85.
Smiles	NCCCC[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity[1][2][3][4].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	956.10
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	H2O : 16.67 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Calmodulin; mGluR; Phosphodiesterase (PDE)
Pathway	Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Peptides

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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