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sPLA2-IIA Inhibitor

sPLA2-IIA Inhibitor

Item no.	HY-P10053
Manufacturer	MedChem Express
CASRN	236394-37-9
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C41H50N8O6
Citations	[1]Kim RR, et al. Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A2. Proteins. 2017;85(5):827-842. doi:10.1002/prot.25235
Smiles	O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC(C)C)=O)CO)=O)CC2=CC3=C(C=CC=C3)C=C2)=O)CCCNC(N)=N)N[C@H]1CC4=CC5=C(C=CC=C5)C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids[1].
Shipping	Room temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	750.89
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	10 mM in DMSO
Target	Others
Manufacturers Target	Others
Manufacturers Pathway	Others
Manufacturers Product type	Peptides

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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