LXW7

Item no.	HY-P0178-1ea
Manufacturer	MedChem Express
CASRN	1313004-77-1
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Formula	C29H48N12O12S2
Citations	[1]Fang T, et al. LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats. Braz J Med Biol Res. 2016 Aug 1;49(9):e5287.<br>[2]Hao D, et al. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086.<br>[3]Xiao W, et al. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct;9(10):2714-23.
Smiles	N[C@H](CSSC1)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@H](CC(O)=O)C(N[C@H](C(C)C)C(N[C@H]1C(N)=O)=O)=O)=O)=O)=O)=O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	LXW7, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect[1][2][3].
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	820.89
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	H2O
Manufacturers Target	Integrin
Pathway	Cytoskeleton
Manufacturers Product type	Peptides

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