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Dehydrocurdione

Dehydrocurdione

Item no.	HY-N8160-0.05ml
Manufacturer	MedChem Express
CASRN	38230-32-9
Amount	0.05 ml
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C15H22O2
Citations	[1]Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897.<br>[2]Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481.
Smiles	C/C(C)=C(CC1=O)/C(C/C(C)=C/CC[C@@H]1C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	234.33
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Manufacturers Product type	Natural Products

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