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Crustecdysone

Crustecdysone

Item no.	HY-N6979-5mg
Manufacturer	MedChem Express
CASRN	5289-74-7
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.63
Formula	C27H44O7
Citations	[1]Liu H, et al. E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body. Insect Biochem Mol Biol. 2014 Feb;45:30-9.<br/>[2]Phungphong S, et al. 20-Hydroxyecdysone attenuates cardiac remodeling in spontaneously hypertensive rats. Steroids. 2017 Oct;126:79-84.<br/>[3]Minglei Lu, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-1645.
Smiles	O[C@@H]1[C@H](O)C[C@](C(C=C2[C@]3([H])CC[C@@]4(C)[C@@]2(O)CC[C@]4([H])[C@](O)(C)[C@H](O)CCC(O)(C)C)=O)([H])[C@]3(C)C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	20-Hydroxyecdysone
Available
Product Description	Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	480.63
Clinical Information	Phase 3
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Autophagy; Caspase; Endogenous Metabolite
Manufacturers Target	Autophagy; Caspase; Endogenous Metabolite
Isoform	Human Endogenous Metabolite
Manufacturers Pathway	Apoptosis; Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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HY-N6979-5mg-safety-datasheet.pdf