KT5823

Item no.	HY-N6791-100ug
Manufacturer	MedChem Express
CASRN	126643-37-6
Amount	100 ug
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.68
Formula	C29H25N3O5
Citations	[1]Gadbois DM, et al. Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30.<br/>[2]Wyatt TA, et al. KT5823 activates human neutrophils and fails to inhibit cGMP-dependent protein kinase phosphorylation of vimentin. Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):3-14.<br/>[3]Chan SL, et al. Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod. 2003 Dec;9(12):775-83.
Smiles	C[C@@]([C@@]1(OC)C(OC)=O)(O[C@](N2C3=C4C=CC=C3)([H])C1)N5C(C2=C4C6=C7CN(C)C6=O)=C7C8=C5C=CC=C8
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	126643-37-6
Similar products	126643-37-6
Available
Product Description	KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively[1]. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells[2]. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[3].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	495.53
Clinical Information	No Development Reported
Manufacturers Research Area	Infection; Inflammation/Immunology
Solubility	DMSO : 20 mg/mL (ultrasonic; warming)
Target	Antibiotic; Apoptosis; Bacterial; PKA; PKC
Manufacturers Target	Antibiotic; Apoptosis; Bacterial; PKA; PKC
Isoform	PKA; PKC
Manufacturers Pathway	Anti-infection; Apoptosis; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Reference compound

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