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Veratridine

Veratridine

Item no.	HY-N6691-10mg
Manufacturer	MedChem Express
CASRN	71-62-5
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Cardiovascular Research Ischemia & Reperfusion Injury Inhibitors & Compound Libraries Small Molecules Arrhythmias
Type	Inhibitors
Specific against	other
Purity	99.96
Formula	C36H51NO11
Citations	[1]Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724.<br/>[2]Laura A Uribe, et al. Supramolecular Complexes of Plant Neurotoxin Veratridine with Cyclodextrins and Their Antidote-like Effect on Neuro-2a Cell Viability. Pharmaceutics. 2022 Mar 9;14(3):598.<br/>[3]Zainab A Mohammed, et al. Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep. 2017 Mar 24;7:45221.
Smiles	C[C@@]12[C@]34[C@](CC[C@]1([H])[C@@](O)([C@@H](OC(C5=CC(OC)=C(OC)C=C5)=O)CC2)O4)([H])[C@@]6(O)[C@](O)([C@@]7([H])[C@@](O)([C@](O)([C@@]8([H])N(C[C@@H](C)CC8)C7)C)[C@@H](O)C6)C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	3-Veratroylveracevine
Similar products	71-62-5
Available
Product Description	Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow[1][2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	673.79
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Sodium Channel
Manufacturers Target	Sodium Channel
Isoform	Nav1.7
Manufacturers Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Natural Products

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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