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Gymnestrogenin

Gymnestrogenin

Item no.	HY-N2273-1ea
Manufacturer	MedChem Express
CASRN	19942-02-0
Amount	1ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.0
Citations	[1]Stöcklin W, et al. [Gymnestrogenin, a new pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br]. Helv Chim Acta. 1968;51(6):1235-42.<br>[2]Renga B, et al. Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists. Steroids. 2015 Apr;96:121-31.
Smiles	OC[C@]1(C[C@H](O)C(C)(C)C2)[C@]2([H])C3=CC[C@@]4([H])[C@@](C)(CC[C@]5([H])[C@@]4(CC[C@H](O)[C@@]5(C)CO)C)[C@]3(C)C[C@@H]1O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	490.72
Clinical_Information	No Development Reported
Manufacturers Research_Area	Metabolic Disease
Solubility	10 mM in DMSO
Manufacturers Target	LXR
Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Natural Products

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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