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Oroxin A

Oroxin A

Item no.	HY-N2025-10mM
Manufacturer	MedChem Express
CASRN	57396-78-8
Amount	10mM/1mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.80
Formula	C21H20O10
Citations	[1]Sun W, et al. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice. Phytomedicine. 2018 Jan 1;38:24-34.<br>[2]He J, et al. Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anticancer Drugs. 2016 Mar;27(3):204-15.
Smiles	O=C1C=C(C2=CC=CC=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C(O)C(O)=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	432.38
Clinical_Information	No Development Reported
Manufacturers Research_Area	Metabolic Disease
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturers Target	Glucosidase; PPAR
Isoform	PPARγ
Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Natural Products

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Amount: 10mM/1mL

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