Item no. |
HY-N0414-50mg |
Manufacturer |
MedChem Express
|
CASRN |
535-83-1 |
Amount |
50 mg |
Quantity options |
100 mg
10 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.98 |
Formula |
C7H7NO2 |
Citations |
[1]Ilavenil S, et al. Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells. Asian Pac J Trop Med. 2015 Apr;8(4):263-8.<br/>[2]Joanna Folwarczna, et al. Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System. Nutrients. 2016 Mar; 8(3): 133.<br/>[3]A Arlt, et al. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene. 2013 Oct;32(40):4825-35.<br/>[4]Ozçelik B, et al. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm Biol. 2011 Apr;49(4):396-402.<br/>[5]Su Y, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020 Jul 28;483:127-136. |
Smiles |
C[N+]1=CC(C([O-])=O)=CC=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Trigenolline |
Similar products |
535-83-1 |
Available |
|
Product Description |
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
Metabolism-protein/nucleotide metabolism |
MolecularWeight |
137.14 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Metabolic Disease |
Solubility |
DMSO : 7.14 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL |
Target |
Apoptosis; Bacterial; Endogenous Metabolite; Ferroptosis; Fungal; HIV |
Manufacturers Target |
Apoptosis; Bacterial; Endogenous Metabolite; Ferroptosis; Fungal; HIV |
Isoform |
Human Endogenous Metabolite |
Manufacturers Pathway |
Anti-infection; Apoptosis; Metabolic Enzyme/Protease |
Manufacturers Product type |
Natural Products |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.