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Trigonelline

Trigonelline

Item no.	HY-N0414-50mg
Manufacturer	MedChem Express
CASRN	535-83-1
Amount	50 mg
Quantity options	100 mg 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Formula	C7H7NO2
Citations	[1]Ilavenil S, et al. Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells. Asian Pac J Trop Med. 2015 Apr;8(4):263-8.<br/>[2]Joanna Folwarczna, et al. Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System. Nutrients. 2016 Mar; 8(3): 133.<br/>[3]A Arlt, et al. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene. 2013 Oct;32(40):4825-35.<br/>[4]Ozçelik B, et al. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm Biol. 2011 Apr;49(4):396-402.<br/>[5]Su Y, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020 Jul 28;483:127-136.
Smiles	C[N+]1=CC(C([O-])=O)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Trigenolline
Similar products	535-83-1
Available
Product Description	Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	137.14
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Metabolic Disease
Solubility	DMSO : 7.14 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Target	Apoptosis; Bacterial; Endogenous Metabolite; Ferroptosis; Fungal; HIV
Manufacturers Target	Apoptosis; Bacterial; Endogenous Metabolite; Ferroptosis; Fungal; HIV
Isoform	Human Endogenous Metabolite
Manufacturers Pathway	Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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