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Yohimbine (Hydrochloride)

Yohimbine (Hydrochloride)

Item no.	HY-N0127-500mg
Manufacturer	MedChem Express
CASRN	65-19-0
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.91
Formula	C21H27ClN2O3
Citations	[1]Docherty JR, et al. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4. [2]Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4. [3]Damase-Michel C, et al. The effect of yohimbine on sympathetic responsiveness in essential hypertension. Eur J Clin Pharmacol. 1993;44(2):199-201. [4]Musso NR, et al. Yohimbine effects on blood pressure and plasma catecholamines in human hypertension. Am J Hypertens. 1995 Jun;8(6):565-71. [5]Sáiz J, et al. Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis. Pharmacol Rep. 2008 May-Jun;60(3):391-8. Eur J Pharmacol. 2023 Nov 6:176174. Exp Neurobiol. 2020 Oct 31;29(5):356-375. Mol Biol Rep. 2020 May;47(5):3629-3639. Mol Med Rep. 2020 Jul;22(1):175-184. Neurosci Bull. 2022 Apr;38(4):386-402. Biomed Pharmacother. 2022 Apr 26;150:113006. Drug Des Devel Ther. 2024 Apr 9:18:1103-1114. Eur J Neurosci. 2021 Nov 4. J Neuroinflammation. 2022 May 27;19(1):123. J Neurophysiol. 2023 Apr 12. Research Square Preprint. 2023 Dec 16.
Smiles	[H][C@]12C(NC3=C4C=CC=C3)=C4CCN1C[C@@]5(CC[C@H](O)[C@H](C(OC)=O)[C@]5(C2)[H])[H].[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	65-19-0
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	Adrenergic Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	390.90
Product Description	Yohimbine hydrochloride is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.
Manufacturer - Research Area	Endocrinology
Solubility	DMSO : 33.33 mg/mL (ultrasonic)\|H2O : 3.33 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	Launched

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HY-N0127-500mg-safety-datasheet.pdf