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Isoliquiritigenin

Isoliquiritigenin

Item no.	HY-N0102-5mg
Manufacturer	MedChem Express
CASRN	961-29-5
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.17
Formula	C15H12O4
Citations	[1]Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.<br>[2]Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890.<br>[3]Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9.<br>[4]Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.<br>[5]Traboulsi H, et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob Agents Chemother. 2015 Oct;59(10):6317-27.
Smiles	O=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GU17; ISL; Isoliquiritigen; SJ000286237
Available
Product Description	Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	256.25
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : ≥ 100 mg/mL\|Ethanol : 100 mg/mL (ultrasonic)
Manufacturers Target	Aldose Reductase; Apoptosis; Autophagy; Influenza Virus
Pathway	Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

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