Tiron

Item no.	HY-D0261-10mM
Manufacturer	MedChem Express
CASRN	149-45-1
Amount	10mM/1mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.94
Formula	C6H4Na2O8S2
Citations	[1]Krishna CM, et al. The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch Biochem Biophys. 1992 Apr;294(1):98-106. 2. <br>[2]El-Sherbeeny NA, et al. Tiron ameliorates oxidative stress and inflammation in a murine model of airway remodeling. Int Immunopharmacol. 2016 Oct;39:172-180. <br>[3]Jiang P, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):760-770. <br>[4]Lu J, et al. Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts. PLoS One. 2016 Aug 3;11(8):e0159998. <br>[5]Monticone M, et al. NAC, tiron and trolox impair survival of cell cultures containing glioblastoma tumorigenic initiating cells by inhibition of cell cycle progression. PLoS One. 2014 Feb 28;9(2):e90085.
Smiles	O=S(C1=C(O)C(O)=CC(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
MolecularWeight	314.20
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Apoptosis; Biochemical Assay Reagents
Pathway	Apoptosis; Others
Manufacturers Product type	Reference compound

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