Item no. |
HY-B1899-50mg |
Manufacturer |
MedChem Express
|
CASRN |
516-50-7 |
Amount |
50 mg |
Quantity options |
100 mg
10mM/1mL
25 mg
50 mg
|
Category |
|
Type |
Inhibitor |
Specific against |
other |
Purity |
98.0 |
Formula |
C26H45NO6S |
Citations |
[1]Benz C, et al. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000 Mar;30(3):203-9. <br/>[2]Xie Q, et al. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601. <br/>[3]Keene CD, et al. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001 Oct;171(2):351-60. <br/>[4]Keene CD, et al. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10671-6. |
Smiles |
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Available |
|
Product Description |
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD)[1][2][3][4]. |
StorageTemperature |
-20°C (Powder, protect from light) |
Shipping |
Blue Ice |
Manufacturers Applications |
Neuroscience-Neurodegeneration |
MolecularWeight |
499.70 |
Clinical Information |
Launched |
Manufacturers Research Area |
Neurological Disease |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Target |
Apoptosis; Endogenous Metabolite |
Manufacturers Target |
Apoptosis; Endogenous Metabolite |
Isoform |
Microbial Metabolite |
Manufacturers Pathway |
Apoptosis; Metabolic Enzyme/Protease |
Manufacturers Product type |
Natural Products |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.