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Rabeprazole (sodium)

Rabeprazole (sodium)

Item no.	HY-B0656A-5mg
Manufacturer	MedChem Express
CASRN	117976-90-6
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.67
Formula	C18H20N3NaO3S
Citations	Front Immunol. 2022 Jun 21;13:895869.<br>Nat Commun. 2023 Jul 14;14(1):4217.<br>[1]Aly A M Shaalan, et al. Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels. Front Pharmacol. 2020 May 13;11:583.<br>[2]Mengli Gu, et al. Rabeprazole Exhibits Antiproliferative Effects on Human Gastric Cancer Cell Lines. Oncol Lett. 2014 Oct;8(4):1739-1744.<br>[3]Tara A Shea, et al. Identification of Proton-Pump Inhibitor Drugs That Inhibit <i>Trichomonas Vaginalis</i> Uridine Nucleoside Ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4.
Smiles	O=S(C1=NC2=CC=CC=C2N1[Na])CC3=NC=CC(OCCCOC)=C3C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY307640 (sodium)
Available
Product Description	Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	381.42
Clinical_Information	Launched
Manufacturers Research_Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 66.67 mg/mL (ultrasonic; adjust pH to 11 with 1M NaOH)
Manufacturers Target	Apoptosis; Bacterial; Proton Pump
Pathway	Anti-infection; Apoptosis; Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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