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Phenytoin-15n2,13c

Phenytoin-15n2,13c

Item no.	HY-B0448S1-1ea
Manufacturer	MedChem Express
CASRN	78213-26-0
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C14 13CH12 15N2O2
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.<br>[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64.<br>[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.<br>[4]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51(5): p. 1379-87.<br>[5]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 2714(1):13.
Smiles	O=C1C(C2=CC=CC=C2)(C3=CC=CC=C3)[15NH][13C]([15NH]1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Phenytoin-15N2, 13C is the 13C and 15N labeled Phenytoin[1]. Phenytoin (5, 5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].
Shipping	Room temperature
MolecularWeight	255.25
Clinical_Information	No Development Reported
Solubility	10 mM in DMSO
Manufacturers Target	Sodium Channel; Virus Protease
Pathway	Anti-infection; Membrane Transporter/Ion Channel
Manufacturers Product type	Isotope-Labeled Compounds

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