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Nicorandil-d4

Nicorandil-d4

Item no.	HY-B0341S-2.5mg
Manufacturer	MedChem Express
CASRN	1132681-23-2
Amount	2.5 mg
Quantity options	10 mg 1 mg 2.5 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.54
Formula	C8H5D4N3O4
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.<br/>[2]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25.<br/>[3]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9.<br/>[4]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65(5):1198-207.
Smiles	O=[N+]([O-])OCCNC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	Nicorandil-d4 (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	215.20
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Target	Isotope-Labeled Compounds; Potassium Channel
Manufacturers Target	Isotope-Labeled Compounds; Potassium Channel
Manufacturers Pathway	Membrane Transporter/Ion Channel; Others
Manufacturers Product type	Isotope-Labeled Compounds

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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