Item no. |
HY-B0341S-10mg |
Manufacturer |
MedChem Express
|
CASRN |
1132681-23-2 |
Amount |
10 mg |
Quantity options |
10 mg
1 mg
2.5 mg
25 mg
5 mg
|
Category |
|
Type |
Molecules |
Specific against |
other |
Purity |
99.54 |
Formula |
C8H5D4N3O4 |
Citations |
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.<br/>[2]Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25.<br/>[3]Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9.<br/>[4]Mitsuhiko Yamada, et al. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Mol Pharmacol. 2004 May;65(5):1198-207. |
Smiles |
O=[N+]([O-])OCCNC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O |
ECLASS 10.1 |
32169090 |
ECLASS 11.0 |
32169090 |
UNSPSC |
12000000 |
Available |
|
Product Description |
Nicorandil-d4 (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Neuroscience-Neuromodulation |
MolecularWeight |
215.20 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cardiovascular Disease |
Solubility |
10 mM in DMSO |
Target |
Isotope-Labeled Compounds; Potassium Channel |
Manufacturers Target |
Isotope-Labeled Compounds; Potassium Channel |
Manufacturers Pathway |
Membrane Transporter/Ion Channel; Others |
Manufacturers Product type |
Isotope-Labeled Compounds |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.