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Ranolazine-d8

Ranolazine-d8

Item no.	HY-B0280S1-5mg
Manufacturer	MedChem Express
CASRN	1092804-88-0
Amount	5 mg
Quantity options	10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.83
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.<br/>[2]Keating GM. Ranolazine: a review of its use as add-on therapy in patients with chronic stable angina pectoris. Drugs. 2013 Jan;73(1):55-73.<br/>[3]Wang WQ, et al. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81.<br/>[4]Zacharowski K, et al. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol. 2001 Apr 20;418(1-2):105-10.
Smiles	O(CC(CN1C(C(N(CC(NC2=C(C)C=CC=C2C)=O)C(C1([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])O)C3=C(OC)C=CC=C3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	Ranolazine-d8 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	435.59
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic; warming)
Target	Calcium Channel; Isotope-Labeled Compounds; Sodium Channel
Manufacturers Target	Calcium Channel; Isotope-Labeled Compounds; Sodium Channel
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Manufacturers Product type	Isotope-Labeled Compounds

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