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Eplerenone-d3

Eplerenone-d3

Item no.	HY-B0251S-1ea
Manufacturer	MedChem Express
Amount	1ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Citations	[1]Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-62.<br>[2]Marvin J Meyers, et al. Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. J Med Chem. 2010 Aug 26;53(16):5979-6002.<br>[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Smiles	O=C(CC1)O[C@@]21CC[C@@]3([H])[C@]4([H])[C@H](C(OC([2H])([2H])[2H])=O)CC5=CC(CC[C@]5(C)[C@@]46[C@H](O6)C[C@@]32C)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Epoxymexrenone-d3
Available
Product Description	Eplerenone-d3 is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch[1][2].
Shipping	Room temperature
MolecularWeight	417.51
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturers Target	Endogenous Metabolite; Isotope-Labeled Compounds; Mineralocorticoid Receptor
Pathway	Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Isotope-Labeled Compounds

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