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Omeprazole-13C,d3

Omeprazole-13C,d3

Item no.	HY-B0113S3-5mg
Manufacturer	MedChem Express
CASRN	1261395-28-1
Amount	5 mg
Quantity options	10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.00
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br/>[2]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.;Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.;Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.
Smiles	CC(C(OC)=C(C=N1)C)=C1CS(C(NC2=C3)=NC2=CC=C3O[13C]([2H])([2H])[2H])=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	H 16868-13CD3
Available
Product Description	Omeprazole-13C, d3 is a 13C-labeled and deuterium labeled Omeprazole. Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
MolecularWeight	349.43
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Infection; Metabolic Disease
Solubility	10 mM in DMSO
Target	Autophagy; Bacterial; Isotope-Labeled Compounds; Phospholipase; Proton Pump
Manufacturers Target	Autophagy; Bacterial; Isotope-Labeled Compounds; Phospholipase; Proton Pump
Manufacturers Pathway	Anti-infection; Autophagy; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Manufacturers Product type	Isotope-Labeled Compounds

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