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Quetiapine (hemifumarate)-d8

Quetiapine (hemifumarate)-d8

Item no.	HY-B0031S4-1ea
Manufacturer	MedChem Express
CASRN	1435938-24-1
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C25H21D8N3O6S
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.<br>[2]Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.<br>[3]Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 219:492.
Smiles	OC(/C=C/C(O)=O)=O.OCCOCCN1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])C2=NC3=CC=CC=C3SC4=CC=CC=C24
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Quetiapine (hemifumarate)-d8 is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].
Shipping	Room temperature
MolecularWeight	507.63
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturers Target	5-HT Receptor; Dopamine Receptor
Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Isotope-Labeled Compounds

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