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Talipexole (dihydrochloride)

Talipexole (dihydrochloride)

Item no.	HY-A0008-5mg
Manufacturer	MedChem Express
CASRN	36085-73-1
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.80
Formula	C10H17Cl2N3S
Citations	[1]Ricci and Taira Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. (1999)32 29.<br/>[2]Eur J Pharmacol. 1997 May 1;325(2-3):137-44.<br/>[3]Kohno Y, Fukuzaki K, Kitahara K, Koja T.Anti-tremor activity of talipexole produced by selective dopamine D2 receptor stimulation in cynomolgus monkeys with unilateral lesions in the ventromedial tegmentum.Eur J Pharmacol. 1997 Jan 29;319(2-3):197-205.<br/>[4]Momiyama T, Sasa M, Takaori S.Inhibition by talipexole, a thiazolo-azepine derivative, of dopaminergic neurons in the ventral tegmental area.Life Sci. 1991;49(7):535-43.<br/>[5]Nishikawa T, Yamada S, Tsuda A, Tanaka M, Koga I, Uchida Y.Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans.Clin Neuropharmacol. 1990 Jun;13(3):259-63.<br/>[6]Robertson, G.S., et al., In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J Pharmacol Exp Ther, 1993. 264(3): p. 1344-51.
Smiles	NC1=NC2=C(CCN(CC2)CC=C)S1.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	B-HT 920 (dihydrochloride)
Available
Product Description	Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	282.23
Clinical Information	Launched
Manufacturers Research Area	Neurological Disease; Endocrinology
Solubility	DMSO : 25 mg/mL (ultrasonic)
Target	5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
Manufacturers Target	5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
Isoform	5-HT3 Receptor; D2 Receptor; α adrenergic receptor
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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