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(4R,5S)-Monomethyl auristatin E intermediate-6

(4R,5S)-Monomethyl auristatin E intermediate-6

Item no.	HY-78899A
Manufacturer	MedChem Express
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C20H29NO5
Citations	[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
Smiles	CC[C@H](C)[C@@H](NC(OCC1=CC=CC=C1)=O)C(CC(OC(C)(C)C)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	(4R, 5S)-Monomethyl auristatin E intermediate-6 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Shipping	Room temperature
MolecularWeight	363.45
Clinical_Information	No Development Reported
Manufacturers Research_Area	cancer
Solubility	10 mM in DMSO
Manufacturers Target	Others
Pathway	Others
Manufacturers Product type	Reference compound

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