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Safinamide

Safinamide

Item no.	HY-70057-5mg
Manufacturer	MedChem Express
CASRN	133865-89-1
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.89
Formula	C17H19FN2O2
Citations	Ecotoxicol Environ Saf. 2023 Aug 7;262:115284.<br>Behav Brain Res. 2023 Nov 30:114787.<br>[1]Leonetti F, et al. Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem, 2007, 50(20), 4909-4916.<br>[2]C Caccia, et al.Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology. 2006 Oct 10;67(7 Suppl 2):S18-23.<br>[3]Michele Morari, et al. Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia.J Pharmacol Exp Ther. 2018 Feb;364(2):198-206.
Smiles	O=C([C@@H](NCC1=CC=C(OCC2=CC(F)=CC=C2)C=C1)C)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	FCE 26743; EMD 1195686
Available
Product Description	Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	302.34
Clinical_Information	Launched
Manufacturers Research_Area	Neurological Disease
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	Monoamine Oxidase
Isoform	MAO-A; MAO-B
Pathway	Neuronal Signaling
Manufacturers Product type	Reference compound

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