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Exatecan intermediate 9

Exatecan intermediate 9

Item no.	HY-43565
Manufacturer	MedChem Express
CASRN	2290562-59-1
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C26H24FN3O5
Citations	[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.
Smiles	O=C(OC1)[C@](O)(CC)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C(C(NC(C)=O)CC6)=C4C3)=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Exatecan intermediate 9 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].
Shipping	Room temperature
MolecularWeight	477.48
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	Others
Pathway	Others
Manufacturers Product type	Reference compound

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