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N-Nitroso-N-methylurea

N-Nitroso-N-methylurea

Item no.	HY-34758-10mM
Manufacturer	MedChem Express
CASRN	684-93-5
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 250 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C2H5N3O2
Citations	[1]Gullino PM, et al. N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Inst. 1975 Feb;54(2):401-14.<br/>[2]Tsubura A, et al. Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 2011 Jan-Feb;25(1):11-22.<br/>[3]Johnson EM, et al. Effects of N-nitroso-N-methylurea on enzymatic ontogeny associated with teratogenesis. Teratology. 1968 May;1(2):179-91.<br/>[4]Silvia Garbarino, et al. One-pot synthesis of α-haloketones employing a membrane-based semibatch diazomethane generator. Journal of Flow Chemistry volume 6, pages211-217(2016).<br/>[5]Moon KY. N-nitroso-N-methylurea and N-nitroso-N-ethylurea induce upregulation of cellular NF-kappa B activity through protein kinase C-dependent pathway in human malignant keratinocytes. Arch Pharm Res. 2010 Jan;33(1):133-9.<br/>[6]Mansingh DP, et al. Palliative Role of Aqueous Ginger Extract on N-Nitroso-N-Methylurea-Induced Gastric Cancer. Nutr Cancer. 2020;72(1):157-169.<br/>[7]Ashrafi M, et al. Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats. DNA Cell Biol. 2015 Nov;34(11):684-91.
Smiles	O=C(N)N(C)N=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NMU; MNU; NMH
Similar products	684-93-5
Available
Product Description	N-Nitroso-N-methylurea (NMU; MNU; NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane[1][2][3][4].
StorageTemperature	-20°C (Powder, protect from light, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	103.08
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)\|H2O : 50 mg/mL (ultrasonic)
Target	DNA Alkylator/Crosslinker
Manufacturers Target	DNA Alkylator/Crosslinker
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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