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Monomethyl auristatin E intermediate-1

Monomethyl auristatin E intermediate-1

Item no.	HY-33048-50mg
Manufacturer	MedChem Express
CASRN	120205-48-3
Amount	50 mg
Quantity options	100 mg 1 g 250 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.93
Formula	C14H30ClNO3
Citations	[1]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
Smiles	CC[C@H](C)[C@H](NC)[C@H](OC)CC(OC(C)(C)C)=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	295.85
Clinical Information	No Development Reported
Manufacturers Research Area	cancer
Solubility	10 mM in DMSO
Target	Others
Manufacturers Target	Others
Manufacturers Pathway	Others
Manufacturers Product type	Reference compound

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