XEN907

Item no.	HY-19958-1mg
Manufacturer	MedChem Express
CASRN	912656-34-9
Amount	1 mg
Quantity options	10mM/1mL 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.23
Formula	C21H21NO4
Citations	[1]Chowdhury S, et al. Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3676-81.<br/>[2]Chowdhury S, et, al. Tetracyclic spirooxindole blockers of hNaV1.7: activity in vitro and in CFA-induced inflammatory pain model. Med Chem Res (2013) 22:1825–1836.
Smiles	O=C(C12COC3=C1C=C(OCO4)C4=C3)N(CCCCC)C5=C2C=CC=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	XEN907 is a potent and spirooxindole blocker of NaV1.7, with an IC50 of 3 nM. XEN907 also inhibits CYP3A4 in a recombinant human enzyme assay. XEN907 can be used for the research of pain[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	351.40
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Sodium Channel
Manufacturers Target	Sodium Channel
Isoform	Nav1.7
Manufacturers Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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