ML289

Item no.	HY-19630-10mM
Manufacturer	MedChem Express
CASRN	1382481-79-9
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.38
Formula	C22H23NO3
Citations	[1]Sheffler DJ, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012;22(12):3921-3925.
Smiles	O=C(N1C[C@H](CO)CCC1)C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VU0463597
Available
Product Description	ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1]. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	349.42
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Target	mGluR
Manufacturers Target	mGluR
Isoform	mGluR3
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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