« Back
Home /
OD36 (hydrochloride)

OD36 (hydrochloride)

Item no.	HY-19628A-1ea
Manufacturer	MedChem Express
CASRN	2387510-88-3
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C16H16Cl2N4O2
Citations	[1]Justine T Tigno-Aranjuez, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.<br/>[2]Gonzalo Sánchez-Duffhues, et al. Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells. JBMR Plus. 2019 Oct 7;3(11):e10230.<br/>[3]Tigno-Aranjuez JT, et al. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J Biol Chem. 2014 Oct 24;289(43):29651-64.
Smiles	ClC1=CC(C2=C3N/C(C=CN3N=C2)=N/CCOCCO4)=CC4=C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 hydrochloride is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 hydrochloride shows ALK2-directed activity with KDs of 37 nM[1][2].
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	367.23
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Target	RIP kinase; TGF-β Receptor
Manufacturers Target	RIP kinase; TGF-β Receptor
Isoform	ALK2; RIPK2
Manufacturers Pathway	Apoptosis; TGF-beta/Smad
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 1 ea

available

Request delivery time