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BRD3308

BRD3308

Item no.	HY-19618-100mg
Manufacturer	MedChem Express
CASRN	1550053-02-5
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.82
Formula	C15H14FN3O2
Citations	[1]Barton KM, et al. Selective HDAC inhibition for the disruption of latent HIV-1 infection. PLoS One. 2014 Aug 19;9(8):e102684.<br>[2]Lundh M, et al. Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats. Diabetes Obes Metab. 2015 Jul;17(7):703-7.<br>[3]Wagner FF, et al. An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol. 2016 Feb 19;11(2):363-74.
Smiles	O=C(C)NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	287.29
Clinical_Information	No Development Reported
Manufacturers Research_Area	Infection; Metabolic Disease
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; HDAC; HIV
Isoform	HDAC1; HDAC2; HDAC3; HIV-1
Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

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