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Siguazodan

Siguazodan

Item no.	HY-19026-5mg
Manufacturer	MedChem Express
CASRN	115344-47-3
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.0
Formula	C14H16N6O
Citations	[1]Tang KM, et al. Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 15;268(1):105-14.<br/>[2]Murray KJ, et al. The effects of siguazodan, a selective phosphodiesterase inhibitor, on human platelet function. Br J Pharmacol. 1990 Mar;99(3):612-6.<br/>[3]Freitag A, et al. Phosphodiesterase inhibitors suppress alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits. Eur J Pharmacol. 1998 Jul 31;354(1):67-71.
Smiles	O=C1CC(C)C(C2=CC=C(/N=C(NC)/NC#N)C=C2)=NN1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SKF 94836
Available
Product Description	Siguazodan (SKF 94836) is a potent, selective and orally active phosphodiesterase III (PDE-III) inhibitor with an IC50 of 117 nM. Siguazodan increases cAMP accumulation in intact platelets with an EC50 of 18.88 μM. Siguazodan also inhibits phenylephrine-induced 5-HT release with an IC50 value of 4.2 μM[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	284.32
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Phosphodiesterase (PDE)
Manufacturers Target	Phosphodiesterase (PDE)
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-19026-5mg-safety-datasheet.pdf