UF010

Item no.	HY-18976-25mg
Manufacturer	MedChem Express
CASRN	537672-41-6
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.84
Formula	C11H15BrN2O
Citations	[1]Mattar P, et al. A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors [J]. Scientific reports, 2021, 11(1): 3858.<br/>[2]Pulya S, et al. Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer [J]. European Journal of Medicinal Chemistry, 2022, 238: 114470.<br/>[3]Dai Y, et al. Classical HDACs in the regulation of neuroinflammation[J]. Neurochemistry International, 2021, 150: 105182.<br/>[4]Yang C X, et al. The inhibitory effects of class I histone deacetylases on hippocampal neuroinflammatory regulation in aging mice with postoperative cognitive dysfunction [J]. European Review for Medical & Pharmacological Sciences, 2020, 24(19).<br/>[5]Pulya S, et al. Selective HDAC3 Inhibitors with Potent In Vivo Antitumor Efficacy against Triple-Negative Breast Cancer [J]. Journal of Medicinal Chemistry, 2023, 66(17): 12033-12058.
Smiles	O=C(NNCCCC)C1=CC=C(Br)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	537672-41-6
Available
Product Description	UF010 is a selective inhibitor of class I HDAC. UF010 has cytotoxicity to cancer cells and reduces neuroinflammation in the hippocampus. UF010 can be used for the research of neurological diseases[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	271.15
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : ≥ 100 mg/mL
Target	HDAC; Interleukin Related; JAK; MyD88; NF-κB; Toll-like Receptor (TLR)
Manufacturers Target	HDAC; Interleukin Related; JAK; MyD88; NF-κB; Toll-like Receptor (TLR)
Isoform	HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; IL-6
Manufacturers Pathway	Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-18976-25mg-safety-datasheet.pdf