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NSC-87877

NSC-87877

Item no.	HY-18756-100mg
Manufacturer	MedChem Express
CASRN	56990-57-9
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.0
Formula	C19H13N3O7S2
Citations	[1]Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.<br/>[2]Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.<br/>[3]Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841.
Smiles	O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O)=O)C=CC4=C3)=C1)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	56990-57-9
Available
Product Description	NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
MolecularWeight	459.45
Clinical Information	No Development Reported
Manufacturers Research Area	Others
Solubility	DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 23.81 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Apoptosis; Phosphatase; SHP2
Manufacturers Target	Apoptosis; Phosphatase; SHP2
Manufacturers Pathway	Apoptosis; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-18756-100mg-safety-datasheet.pdf