Yoda 1

Item no.	HY-18723-1mg
Manufacturer	MedChem Express
CASRN	448947-81-7
Amount	1 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Formula	C13H8Cl2N4S2
Citations	[1]Syeda R, et al. Chemical activation of the mechanotransduction channel Piezo1. Elife. 2015 May 22;4.<br>[2]Dela Paz NG, et al. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018 Feb 26;497(1):220-225. <br>[3]Kuriyama M, et al. Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells. Sci Rep. 2022 Apr 15;12(1):6322.
Smiles	ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	355.27
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cardiovascular Disease
Solubility	DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)\|Ethanol : 5 mg/mL (ultrasonic)
Manufacturers Target	Akt; ERK; Piezo Channel; Potassium Channel
Isoform	ERK1; ERK2
Pathway	MAPK/ERK Pathway; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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