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Leupeptin

Leupeptin

Item no.	HY-18234-1ea
Manufacturer	MedChem Express
CASRN	55123-66-5
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C20H38N6O4
Citations	Biochim Biophys Acta Mol Cell Res. 2023 Jan 24;1870(3):119433.<br>Carbohydr Polym. 2023 Jun 9, 121108.<br>Emerg Microbes Infect. 2023 Apr 26;2207688.<br>Int J Biol Macromol. 2023 Jul 3;125670.<br>Nature. 2023 Jun;618(7966):799-807.<br>Redox Biol. 2024 Apr:70:103064.<br>Redox Biol. 2024 Mar 8, 103100.<br>Antiviral Res. 2020 Oct;182:104922.<br>Autophagy. 2021 Aug;17(8):1873-1888.<br>Autophagy. 2021 Jul;17(7):1592-1613.<br>Biochem Pharmacol. 2022: 115339.<br>bioRxiv. 2020 Jun.<br>bioRxiv. 2023 Nov 5.<br>Br J Pharmacol. 2023 Feb 14.<br>Cancer Lett. 2022 Mar 9;215629.<br>Cell Death Differ. 2022 Aug 22.<br>Cell Death Dis. 2022 Oct 12;13(10):865.<br>Cell Rep. 2021 Nov 2;37(5):109931.<br>Environ Toxicol. 2023 Nov 23.<br>Int J Oncol. 2019 Jul;55(1):331-339.<br>J Biol Chem. 2021, 100616.<br>J Clin Invest. 2022 Mar 1;132(5):e152170.<br>Mol Biomed. 2023 Nov 17;4(1):42.<br>Natl Sci Rev. 2021 Feb 10;8(7):nwab024.<br>Neuro Oncol. 2022 Jun 21;noac157.<br>Oncol Rep. 2021 Dec;46(6):253.<br>Sci Adv. 2021 Jan 1;7(1):eabe1340.<br>Sci Rep. 2022 Jul 16;12(1):12197.<br>Toxicol Appl Pharmacol. 2023 May 26;116568.<br>[1]Fu L, et al. Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs. mBio. 2021 Oct 26;12(5):e0222021.<br>[2]Haspel J, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42.<br>[3]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.<br>[4]Aoyagi T, et al. Biological activities of leupeptins. J Antibiot (Tokyo). 1969 Nov;22(11):558-68.
Smiles	O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Leupeptin is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin potently inhibits serine, cysteine and threonine proteases. Leupeptin inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
Shipping	Room temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	426.55
Clinical_Information	No Development Reported
Manufacturers Research_Area	Infection; Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturers Target	Cathepsin; Ser/Thr Protease; Virus Protease
Pathway	Anti-infection; Metabolic Enzyme/Protease
Manufacturers Product type	Peptides

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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